Replicating the MAP Kinase Cascade in Membrane Computing

نویسندگان

چکیده

Abstract Membrane Computing (MC) is defined as one of the main areas in computer sciences; MC has aim discovering novel computational models from studying biological cells, specifically cellular membranes. Mitogen-Activated Protein Kinases (MAPK) cascade was subject research modeling and simulation. Various software tools such Performance Evaluation Process Algebra (PEPA) have been used to solve MAPK for purpose improving effectiveness signaling. In this study, modeled by using MC. The could be totally fully utilized applying parallel computing platforms. P-Lingua can a programming language MeCoSim MC, where simulators are model simulate MAPK. will applied structure, develop examine implementation cascades membrane computing. supports charts, outputs, inputs which adapted simulation results put comparison with PEPA model. indicate that improves compared PEPA. This study showed its characteristics, improve regarding processes including

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Replicating the MAP Kinase Cascade in PEPA

Abstract. Ordinary Differential Equations (ODEs) represent a powerful technique for analysing biological systems. ODEs can cope with large numbers of components involved in multiple interactions. ODEs also bring a certain level of complexity through the reactions and the combinations of components within these reactions. Using the MitogenActivated Protein (MAP) Kinase cascade, it will be shown ...

متن کامل

Sustained oscillations in the MAP kinase cascade.

The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This paper focusses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits. Furthermore it is explained how geometric singular pertu...

متن کامل

Membrane Localization of Scaffold Proteins Promotes Graded Signaling in the Yeast MAP Kinase Cascade

BACKGROUND Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show various input-output behaviors, including either switch-like or graded responses to increasing levels of stimulus. Prior studies suggest that switch-like behavior is promoted by positive feedback loops and nonprocessive phosphorylation reactions, but it is unclear whether graded signaling is a default...

متن کامل

Dystroglycan, a scaffold for the ERK-MAP kinase cascade.

Dystroglycan is an important cell adhesion receptor linking the actin cytoskeleton, via utrophin and dystrophin, to laminin in the extracellular matrix. To identify adhesion-related signalling molecules associated with dystroglycan, we conducted a yeast two-hybrid screen and identified mitogen-activated protein (MAP) kinase kinase 2 (MEK2) as a beta-dystroglycan interactor. Pull-down experiment...

متن کامل

Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.

A continuing focus of our work has been an effort to understand the signal transduction pathways through which insulin achieves its cellular actions. In the mid-1970s, we and others observed that insulin promoted an increase in Ser/Thr phosphorylation of a subset of cellular proteins. This finding was unanticipated, inasmuch as nearly all of the actions of insulin then known appeared to result ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of physics

سال: 2021

ISSN: ['0022-3700', '1747-3721', '0368-3508', '1747-3713']

DOI: https://doi.org/10.1088/1742-6596/1963/1/012156